PDP1 and neoplasm: By inhibiting PDK in tumor cells, DCA stimulates PDH and oxidative phosphorylation, decreases tumor lactate concentration, and initiates a caspase-mediated chain of reactions leading to apoptosis of tumor, but not of host, cells (Bonnet et al. 2007) [see Supplemental Material, Text G (doi:10.1289/ehp.1002554)].