Even if the analysis of the pre-transcriptional steps of the NF-κB pathway did not reveal significative differences upon GSK-3α or β inactivation (data not shown), it is still possible, as already reported by other studies [34], that, even in MM cells, GSK-3β regulates NF-κB transcriptional activity directly on DNA. The gene discussed is GSK3B; the disease is Miyoshi myopathy.