GSK-3β also resulted more phosphorylated in Ser 9 than GSK-3α in Ser 21 both in normal and malignant samples; moreover, in the MM samples analyzed for GSK-3 Tyr phosphorylation, we found that GSK-3β was much less Tyr phosphorylated than GSK-3α (Fig. 1A). The gene discussed is GSK3A; the disease is Miyoshi myopathy.