In accordance with the explanations raised by Guerreiro et al., - regarding the controversial results of previous published studies about the CRC risk modified by the interaction of folate intake and MTHFR 677 polymorphism -, we accept the following statement: the low folate intake and the presence of MTHFR 677T allele or TT genotype predicts if there is an increased risk of CRC, while on the contrary high/adequate folate intake results in a risk reduction if the variant allele is present [11]. Here, MTHFR is linked to colorectal carcinoma.