CKS2 and breast cancer: A model including hTR and CKS2 was the best one in BC diagnosis (Table 3) and showed a higher clinical performance in comparison to each single tested marker (AUChTR = 0.71, 95% CI: 0.60-0.82; AUChTERT = 0.74, 95% CI: 0.625-0.86; AUCCKS2 = 0.66, 95% CI: 0.53-0.79; AUChTR/CKS2 = 0.87, 95% CI: 0.78-0.96) (Figure 4).