The AUCs values were 0.88 (95% CI: 0.78-0.95) for hTR, 0.78 (95% CI: 0.65-0.88) for hTERT and 0.72 (95% CI: 0.60-0.82) for CKS2. Finally, the ability to significantly discriminate between superficial and invasive BC was evaluated only for hTR transcript level (AUC: 0.78, 95% CI: 0.60-0.90, P = 0.0005). This evidence concerns the gene CKS2 and breast cancer.