However, considering the known imbalance in glutamate-to-GABA ratios in children with autism [14], the higher levels of glutamate in autism [14], the downregulation of GABA(A) receptors in autism [15], and the role of NT in excessive activation of the NMDA receptor and apoptosis [3,4], NT may mediate brain damage in addition to activating inflammatory processes in autism. The gene discussed is NTS; the disease is autism.