The parallel trial, Telmisartan Randomized AssessmeNt Study in aCE iNtolerant Subjects with Cardiovascular Disease (TRANSCEND®), in nearly 6,000 patients intolerant of ACE inhibitors, showed that telmisartan significantly reduced the cardiovascular composite of cardiovascular death, myocardial infarction and stroke (although not heart failure) compared with placebo, when administered on a background of otherwise optimal standard of care [3]. This evidence concerns the gene ACE and myocardial infarction.