Focused analysis of biomarkers (at protein level) associated with hypertension (angiotensin converting enzyme: ACE), endothelial activation (endothelin-1: ET-1), coagulation factors (tissue factor: TF; plasminogen activator inhibitor-1: PAI-1), atherosclerosis (vascular cell adhesion molecule 1: VACM-1) and angiogenesis (vascular endothelial growth factor: VEGF) was performed from the lung and heart. The gene discussed is CUL5; the disease is Hypertension.