In one study [37] anemia (defined using a probable criterion of only Hb <90 g/L [39]) occurred less frequently in patients taking LDA at a dose of less than 162 mg daily than in those taking LDA 162-325 mg daily, 70 patients (3.0%) versus 97 patients (4.4%) (p = 0.011). Here, GSTM1 is linked to anemia (phenotype).