Moreover, the current study represents the first evidence for DNA hypermethylation of NPY, FGF2, CD40, TAL1, JAK3, SPARC, PRKCDBP, DBC1, SOX1, TNFRS10D, Let-7a, Mir-10a, and Mir-93 and hypomethylation of VAMP8 in breast cancer. This evidence concerns the gene JAK3 and breast cancer.