The aim of our study was to evaluate associations between cachexia due to weight loss and APRPs (albumin, C-reactive protein (CRP)), cytokines (IL-1α, IL-1β, IL-6, IL-10, TNF-α, IL-8, VEGF-A, VEGF-C), midkine and hormones (adiponectin, leptin and ghrelin) in a population of newly diagnosed colon cancer patients. This evidence concerns the gene TNF and malignant colon neoplasm.