NFKB1 and Miyoshi myopathy: However, progression events that can occur in all of the different molecular subtypes of MM include: additional cytogenetic and epigenetic abnormalities, activating mutations of N- and K-RAS, AKT pathway mutations, NFkB pathway mutations, p53 deletion or mutation, RB1 or p18CDKN2c inactivation, and MYC rearrangements[2, 6-10].