In the past, several small studies have shown no effect of HBV infection on acute dengue morbidity,14,15 but our findings are in agreement with a recent study in which nearly 400 patients with dengue-1 virus infection were studied and showed slightly greater increases in ALT levels among patients with HBV co-infection.23 We found no clinically significant effects in our study, but the possibility that repeated dengue infections may alter the rate of progression of the HBV infection needs to be considered. The gene discussed is GPT; the disease is coinfection.