Krabbe disease, also known as globoid-cell leukodystrophy (GLD; MIM# 245200), is an autosomal recessive disorder resulting from the deficiency of galactocerebrosidase (GALC; E.C. 3.2.1.46), a lysosomal enzyme involved in the catabolism of galactosylceramide, a cerebroside located mainly in the myelin sheath. This evidence concerns the gene GALC and Krabbe disease.