GALC and Krabbe disease: The GALC mutational profile differs between European and Japanese Krabbe disease patients; thus, whilst the most common large deletion, c.1161+6532_polyA+9kbdel (IVS10del30kb) plus three other mutations [c.1586C>T, c.1700C>T, c.1472delA (1538C>T, 1652A>C, 1424delA)] together account for about 60% of alleles in patients of European ancestry with the classic infantile form [Kleijer et al., 1997; Wenger et al., 1997], these lesions are absent in their Japanese counterparts.