MYD88 and bacterial urinary tract infection: This study addressed this question with the aim to define the genetic control of TcpC mediated immune inhibition in vivo. We used the murine UTI model and mice lacking specific innate immune response genes to examine whether Myd88 controls the TcpC dependent response to UPEC infection and if additional Myd88 independent signaling pathways might modify the effects of TcpC in vivo.