Because muscle wasting is a cardinal feature of KD/SBMA and wasting is present in all 3 models, we were not surprised to find Fbxo32 in all of the gene lists (Table S4 and Table 1) However, Fbxo32 was unexpectedly decreased in all 3 models, whereas increases in Fbxo32 were observed in other cases of muscle wasting, including diabetes, renal failure, cancer and denervation [15], [30]. The gene discussed is FBXO32; the disease is Renal insufficiency.