ENO1 and brain neoplasm: It is interesting to note that the ENO1 gene, encoding α-enolase and MBP-1, is located in the distal short arm of chromosome 1 [34] within one of the most frequent regions of loss of heterozygosity (LOH) observed in node negative breast cancers with poor prognosis [35], as well as brain tumors and hematopoietic neoplasms, suggesting that MBP-1 could be a candidate tumor suppressor in that region.