In fact, one of the phenotypic characteristics of the treatment with CLA in the present study concerns the maintenance of glucose-insulin homeostasis, which is unaltered in Exp1 [22] and, despite moderate hyperglucemia and hyperinsulinemia in Exp2, insulin sensitivity, assayed by the revised quantitative insulin sensitivity check index is preserved in this experimental setting [23]. This evidence concerns the gene INS and Hyperinsulinemia.