Although little is known about the adipocyte biology of both miRNAs, treatment of differentiated 3T3-L1 adipocytes for 24 h with TNFα has been shown to induce expression of both miRNAs, which has been associated with the role of TNFα, as a major macrophage-produced cytokine involved in chronic inflammation [11], being largely responsible for inducing insulin resistance in obese adipose tissue [33]. The gene discussed is TNF; the disease is Insulin resistance.