RAF1 and chronic myelogenous leukemia, BCR-ABL1 positive: In the case of glycation, it is known that CML-modified proteins are substrates for ubiquitin conjugation [41] and that, for example, Raf-1 is degraded by an ubiquitin-proteasome-dependent mechanism in response to MGO [65], suggesting increased ubiquitination of glycated proteins and the existence of a crosstalk between both processes.