But the phosphorylation sate of p38, Erk1/2, and JNK1/2 were all activated in rat enteritis mucous of MTX group, then we found that treatment with curcumin or NAC resulted in a reduction in p38 phosphorylation (p = 0.000), but not of that in Erk1/2 and JNK1/2 (Fig. 7). The gene discussed is MAPK3; the disease is enteritis.