DSG2 and pemphigus foliaceus: The paper entitled “Suprabasal Dsg2 expression limits epidermal blister formation mediated by pemphigus foliaceus antibodies and exfoliative toxins” by D. Brennan et al. demonstrates that, upregulation of Dsg2 in the upper epidermis of mice can compensate for a loss of Dsg1 function induced by pathogenic pemphigus foliaceus antibodies or exfoliative toxins, thus preventing blistering.