Mice ablated of TLR2, TLR4, TLR9, or their common adaptor molecule MyD88, were more acutely susceptible to colitis induced by the chemical colitogen dextran sodium sulfate (DSS), due in part to impaired protective responses and reduced prostaglandin production [7], [8], [9], [10], [11]. The gene discussed is MYD88; the disease is colitis.