Therefore, other types of colitis models are widely used, including a transfer colitis model produced by transfer of a T-cell population (CD4+CD45RBhigh T cells) that lacks regulatory cells into an immunodeficient host, spontaneous colitis model such as the SAMP/Yit mouse, and genetic colitis model such as interleukin IL-10-deficient mice. Here, IL10 is linked to colitis.