STAT3 and neoplasm: On the other hand, STAT3 activation inhibits NF-κB/c-Rel-dependent IL-12p35 gene expression in tumor-associated DCs, possibly through the STAT3-dependent induction of the ETS transcriptional suppressor, ETS variant gene 3 (ETV3), and the helicase family corepressor, strawberry notch homolog 2 (SBNO2).