However, since IGF-I infusion causes hypoglycemia, primarly by stimulating peripheral glucose uptake [51], and IGFBPs buffer the acute hypoglycemic effect of IGF-I [52], we thus speculate that the alterations in IGF-I and IGFBP-1 levels may be an adaptive response to prevent hypoglycemia following insulin-sensitizing training. This evidence concerns the gene IGFBP1 and Hypoglycemia.