In DM1 myoblasts, CUGBP1 is hyperphosphorylated by Akt; whereas in DM1 myotubes CUGBP1 phosphorylation by cyclinD3/cdk4 is reduced due to low levels of cytoplasmic cyclin D3 [68]. This evidence concerns the gene AKT1 and myotonic dystrophy type 1.