Indeed, application of LNA-CAG probe and inclusion of Triton X-100 in the hybridization buffer for detection of mutant DMPK mRNA revealed multiple cytoplasmic aggregates of mutant DMPK mRNA in cytoplasm and in nuclei of DM1 myoblasts (Dr. Partha Sarkar, personal communication). Here, DMPK is linked to myotonic dystrophy type 1.