In polyglutamine repeat diseases such as HD, frontotemporal lobar degeneration, and RNA-mediated diseases such as myotonic dystrophy, inclusion-mediated titration of transcription factors (like CBP), tar DNA-binding protein 43 (TDP-43), and RNA splicing factors (for example muscleblind), respectively, may represent an important molecular mechanism of disease [6]. The gene discussed is TARDBP; the disease is Huntington disease.