INS and pulmonary edema: NCPE is clearly associated with several agents that have vastly different pharmacological functions (few of them are Methadone, Naloxone, Tocolytics, Salicylates, Hydrochlorthiazide, Protamine, Recombinant interleukin-2, Amiodarone, Bleomycin, insulin, streptokinase, lidocaine, and intrathecal methotrexate).[11] Pulmonary oedema has also been reported due to administration of propofol,[12] hydrochlorthiazide,[13] ondansetron.[14]