INS and type 2 diabetes mellitus: In this study, two progressive approaches to starting and intensifying insulin therapy are compared in patients with T2D and inadequate glycaemic control on oral therapy: premix insulin progression (PP) with once- then twice- or thrice-daily LM50/50 insulin administration vs. basal insulin glargine initiated once daily then supplemented with one to three prandial insulin (lispro) injections [insulin glargine plus insulin lispro (G+L)] as needed to meet glycaemic targets.