NPM1 fusion proteins are also specifically involved: t(5;17)(q35;q21)/NPM1-RARA causes acute promyelocytic leukemia; t(2;5)(p23;q35)/NPM1-ALK underlies anaplastic large cell lymphoma; t(3;5)(q26;q35)/NPM1-MLF1 is associated with myelodysplastic syndromes (MDS) and AML with trilineage dysplasia and poor prognosis (http://AtlasGeneticsOncology.org). This evidence concerns the gene NPM1 and anaplastic large cell lymphoma.