Among the L/R pairs upregulated in tumor samples were genes involved in: chemokine pathways (CCL13/CCR1, 2 datasets), growth pathways (INHBB/ACVR1, 4 datasets; TGFA/EGFR, 2 datasets; TNC/ANXA2, 4 datasets), and motility and adhesion (PLAU/PLAUR, 2 datasets; SEMA3F/NRP2, 4 data sets; SPP1/ITGAV, 3 datasets; SPP1/CD44, 3 datasets; SPP1/ITGA9, 2 datasets). This evidence concerns the gene SPP1 and neoplasm.