Proteins encoded by HIV, including Vpr, Nef, Vif, Vpu, Tat, and Rev, initially impede programmed cell death, allowing for proliferation of HIV-infected cells, then gradually shift to actively induce apoptosis of CD4-T cells, macrophages, monocytes, and microglial cells, thus causing the hallmark global immunodefiency of AIDS [7]. This evidence concerns the gene CD4 and AIDS.