The most frequent form of p53 mutations are of the missense type and can result in an increased half-life of the p53 protein, making it detectable by immunohistochemistry.[7] Several previous studies have shown that alterations of the p53 are less frequent in prostate cancer than in other common tumors.[8–10] The prevalence of p53-positivity in prostate tumors has been found in the range of 4% -60%.[11, 12] Our study showing 42% p53 immune staining falls in between. This evidence concerns the gene TP53 and Familial prostate cancer.