NPHS2 and focal segmental glomerulosclerosis: Human genetic studies have helped to identify genes that are involved in the development of FSGS such as podocyte-specific gene nephrosis 2 homolog, podocin (NPHS2) [6], [7], α-actinin-4 (ACTN4) gene that encodes for a ubiquitously expressed cytoskeletal protein [8], Transient receptor potential channel 6 (TRPC6) gene which encodes for a calcium channel [9], [10] and INF2 gene which encodes a member of the formin family of actin-regulating proteins [11].