In R6/2 mice high expression levels of a mutant huntingtin exon I fragment containing ~160 CAG repeats lead to early neurological phenotype and premature death at 110-120 days [7] We assessed expression levels of HDAC1 and HDAC3 proteins in cortex and striatum, the primary brain areas affected by HD, of R6/2 transgenic mice and wild-type littermates. This evidence concerns the gene HDAC3 and Huntington disease.