The C-terminal transactivation domain (C-TAD786-826) of hypoxia-inducible factor 1α (HIF-1α) features two α-helical regions which mediate binding to the CH1 region of the two proteins CBP and p300, thereby initiating transcription of hypoxia-inducible genes, e.g., genes encoding vascular endothelial growth factor (VEGF) and its receptor VEGFR2, which play important roles in cancer growth (angiogenesis) and metastasis. This evidence concerns the gene VEGFA and cancer.