It induced oligonucleosomal fragmentation of DNA in melanoma cells and increased caspase-3, 8, 9 activities followed by the degradation of caspase-3 substrates, inhibitor of caspase dependent DNase (ICAD) and PARP indicating that magnolol induces apoptosis by activation of both mitochondrial and death receptor pathways in melanoma cells [52]. The gene discussed is CASP3; the disease is melanoma.