On the other hand, corresponding with our Acosta et al. [87] findings in ovary-intact animals that higher LH levels correlated with worse cognitive performance, in ovary-intact aged female mice, experimentally-induced LH reductions decreased amyloid-β concentrations and enhanced cognition, while LH increases promoted biochemical brain changes consistent with AD, although none of these studies correlated circulated LH levels with memory scores in individual animals [227,228,229]. The gene discussed is PLOD1; the disease is Alzheimer disease.