Supporting plausibility of LH effects on spatial cognition, the highest density of LH receptors in the brain is found in the hippocampus [222,223], and LH-releasing hormone has been found in a neuronal-derived septal cell line with cholinergic properties [224], suggesting the presence of LH effects in regions intimately involved in spatial learning and memory which are also affected by aging and AD. The gene discussed is PLOD1; the disease is Alzheimer disease.