TP53 and Alzheimer disease: Evidence in mice and humans suggest that p53 acts as a longevity-assurance gene, basically reducing the influence of tumorigenesis [53,54].Our group has studied p53 in fibroblasts from aged controls and demented patients finding that with aging there is an increase in the expression of an unfolded protein state, which is more pronounced in AD patients and is not dependent on gene mutations [55].