Upon addiction of micromolar amounts of Zn2+, the protein undergoes a refolding to the native form and reacquires DNA-binding competence [56].Trying to investigate the cause of this alteration we found that the exposure to nanomolar concentrations of the beta-amyloid peptide 1-40 (Aβ 1-40) induced the expression of the unfolded p53 protein isoform in fibroblasts derived from non-AD subjects [3]. This evidence concerns the gene TP53 and Alzheimer disease.