Previous reports have shown that the Eng gene is located at 9q34.1 and that mutations of this gene having reduced Eng expression are responsible for one of the two types of hereditary hemorrhagic telangiectasia, an autosomal dominant disorder characterized by multiple telangiectasia of the skin, mucous membranes, gastrointestinal tract, arteriovenous malformation, and pulmonary hypertension [29]. This evidence concerns the gene ENG and hereditary hemorrhagic telangiectasia.