Similar to the results of Akiyama et al. [80], Yoon et al. [20] provided evidence that fenofibrate is involved in obesity, but not likely to have an effect on obesity mainly through PPARα-mediated action since it increases FA β-oxidation and decreases serum triglycerides in female mice, although their effects are much lower compared with males [20]. Here, PPARA is linked to obesity due to melanocortin 4 receptor deficiency.