ADIPOQ and polycystic ovary syndrome: Also the association between Pro12Ala and adiponectin plasma levels seems controversial: in the Japanese population Ala12 allele is associated with reduced serum adiponectin levels [94, 96] whereas no significant effect of this polymorphism on serum adiponectin was observed in polycystic ovary syndrome, healthy women, and in Asian Indians [98, 101].