PPARs have a great relevance in the human physiology, but they are also involved in the etiology of many human diseases, and, in this contest, PPARγ is of particular interest because of its pleiotropic functions: it plays a dominant role in the control of the expression of a plethora of genes related to a wide spectrum of physiological processes, such as adipose cell differentiation, metabolism, atherosclerosis, inflammation, and cancer. Here, PPARG is linked to atherosclerosis.