The effect of Pro12Ala on increased leptin levels is likely to be supported by a study in women with functional hyperandrogenism (FOH), in which the authors demonstrated that Ala allele was more frequent in FOH women than in healthy controls (36% versus 28%) and that leptin levels were higher in nonobese FOH women compared to controls [100]. The gene discussed is LEP; the disease is hyperandrogenism.