PDGFC and neoplasm: For example, in tumors overexpressing PDGF-C, treatment with an anti- VEGFR-2 antibody, which blocks the VEGF pathway, had no effect on tumor angiogenesis, while it decreased blood vessel density in the control tumors without PDGF-C overexpression, demonstrating that the PDGF- C-induced angiogenesis was not mediated by the VEGF pathway [17].