PDGFC and neoplasm: Indeed, this notion was further supported by the findings that in VEGF-deficient fibrosarcomas, tumor angiogenesis still developed without VEGF, and the PDGFR-α-mediated recruitment of stromal fibroblasts was believed to be responsible for the persistent tumor angiogenesis [29], further affirming a VEGF-independent tumor angiogenesis induced by PDGF-C.