Septicemia is not only associated with high mortality[1] but it can also induce liver damage and liver injury by various mechanisms, including release of per-oxynitrite by leucocytes resulting in damage to the membrane of tissue cells,[3] apoptosis of the immune system[4] and tissue ischemia due to microvascular obstruction.[5, 6] It is believed that microvascular obstruction is triggered by the release of pro-inflammatory mediators such as tumor necrosis factor (TNF) α and IL-1 by tissue macrophages in response to septicemia.[7, 8]. Here, TNF is linked to Sepsis.