Among them, seven polymorphisms (ADAM33 T1-C/T, ACE D/I, FcεRIβ -6843G/A, IL-13 -1923C/T, IL-13 -2044A/G, RANTES -28C/G and TNF-α -308G/A) were statistically associated with increased risk of asthma. Here, ACE is linked to asthma.