Because the fixed-effect model is more precise than random effect model, the strength of evidence of ADAM33 T1-C/T, ACE D/I, IL-13 -1923C/T, RANTES -28C/G, as risk factors for asthma was greater than that of FcεRIβ -6843G/A, IL-13 -2044A/G and TNF-α -308G/A. Here, ACE is linked to asthma.