The ACE D/I, β2-AR -79G/C, TNF-α -308G/A, IL-4R -1902G/A and IL-13 -1923C/T polymorphisms were found being associated with asthma risk in Chinese children, while the ACE D/I, FcεRIβ -6843G/A, TNF-α -308G/A, IL-13 -1923C/T, IL-13 -2044A/G polymorphisms were associated with asthma risk in Chinese adults. Here, ACE is linked to asthma.