In particular, the BNMN frequency, as well as RFC1 80AA, MTHFR 677TT, MTR 2756AA, TYMS 1494 6bp del +/+ and TYMS 28bp 3R/3R polymorphisms resulted the most important variables for discriminating between MDS and control mothers (Table 3). The gene discussed is MTHFR; the disease is myelodysplastic syndrome.