Mn-treated C. elegans recapitulate essential physiological aspects of parkinsonism, namely: the importance of NRAMP/DMT orthologues in the toxicity process [107], [108], [109]; the specificity and dose-dependency of the DAergic neurodegeneration [110], [111]; the involvement of DAT [112], [113], [114]; the synergy between DA and Mn [115]; and the associated oxidative stress [116], [117], [118]. This evidence concerns the gene SLC6A3 and Parkinson disease.