SLC6A3 and Parkinson disease: Rather than being responsible for cytosolic DA accumulation followed by downstream ROS production, which was considered as the reason for the sensitivity of DAergic neurons to PD-mimicking drugs (MPP+, 6-OHDA) [56], [114], [121], [122], DAT may facilitate the transport of extracellulary oxidized DA-derived species into DAergic neurons.