Combined with the absence of post-synaptic neurodegeneration in dop-1::GFP and dop-3::RFP-expressing worms upon Mn exposure (data not shown) and despite the excitotoxic potential of other DA-related compounds, such as L-DOPA and 6-OHDA [119], the results establish that DA-dependent Mn toxicity does not involve excitotoxicity, in contrary to the glutamate-induced neurodegeneration involved in amyotrophic lateral sclerosis (ALS) [120]. The gene discussed is OPRD1; the disease is amyotrophic lateral sclerosis.