CD4+ cells from individuals homozygous for CCR5Δ32 are resistant to infection by CCR5-using HIV-1 isolates in vitro but permissive for strains that can use CXCR4, and the essential role for CCR5 in HIV-1 transmission and infection is demonstrated by the finding that individuals homozygous for CCR5Δ32 are highly resistant to infection [39], [40]. Here, CCR5 is linked to infection.