Although all three Gli proteins are implicated in stem cell biology, development and disease pathogenesis [85], [86], evidence suggestive of crosstalk with MAPK signaling is especially enticing for Gli1 [76], [77], [78], [79], [80], [81], [82], particularly in relation to a role in tumorigenesis and cancer progression [87], [88]. Here, GLI1 is linked to cancer.