In our study, we examined the HER-2 status of several EAC cell lines and showed that OE33 and OE19 are characterized by high levels of HER-2 gene amplification, confirming previous findings [9], whereas SW620, a HLA-A2 positive colon cancer cell line taken as control, is characterized by only polysomy of chromosome 17. This evidence concerns the gene ERBB2 and malignant colon neoplasm.