Investigation of the status of several components of the Antigen Processing Machinery (APM) in this cell line and in EAC tumor biopsy specimens showed that the expression of one of the most important components of the APM, the Transporter Associated with Antigen Processing-2 (TAP-2) is specifically down regulated in OE19 and also in a high percentage of EAC. Here, TAP2 is linked to neoplasm.