In addition, omalizumab has been reported to ameliorate the symptoms of chronic urticaria in an uncontrolled study of three patients, two of whom also had IgE-mediated asthma.8–11 An explanation for these observations could be decreased expression of surface IgEfcR due to omalizumab administration.12, 13 In our patients, the mean UAS decreased, the mean rescue medication use declined, and overall therapeutic response and quality of life improved after omalizumab use. The gene discussed is IGHE; the disease is asthma.